International Journal Of Medicine Papers <p><strong>ISSN: 2518-0762</strong></p> <p>International Journal of medicine papers is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of medicine. International Journal of medicine papers is an international peer review publication, the aim of which is to provide a scientific medium of communication for researchers throughout the globe. The Journal welcomes clinical articles as well as basic science research experiences. Manuscripts are publishable in the form of original article, review article, case report, letter to the editor, etc. International Journal of medicine papers is freely available for readers and researchers and apart from articles processed under our fast track system. International Journal of medicine papers aims to publish the highest quality material, both clinical and scientific, on all aspects of Medicine and Surgery. It includes articles related to research findings, technical evaluations, and reviews. In addition it provides a forum for the exchange of information on all aspects of Medicine and Surgery, including educational issues.&nbsp;</p> <p><em><strong>Submission</strong></em></p> <p><strong>Authors can send their papers through online submissions or as an email attachment to:</strong> <a href=""></a></p> <p>&nbsp;</p> <p><a href="">Impact Factor=1.38</a>&nbsp;</p> <p><strong>Indexed in:</strong></p> <p><strong>Index Copernicus,</strong></p> <p><strong>CiteFactor,</strong></p> <p><strong><span class="tagline">Genamics JournalSeek,</span></strong></p> <p><strong><span class="tagline"> Geneva Foundation for Medical Education and Research</span>,</strong></p> <p><strong> J-Gate ,</strong></p> <p><strong> Scientific World Index,</strong></p> <p><strong> Science Library Index,</strong></p> <p><strong> JournalGuide Directory of Journals, </strong></p> <p><strong>SlideShare,</strong></p> <p><strong>ResearchBib, </strong></p> <p><strong><span class="tagline">Scientific Indexing Services (SIS database),</span></strong></p> <p><strong><span class="tagline"> International Innovative Journal Impact Factor,</span></strong></p> <p><strong><span class="tagline"> International Committee of Medical Journal Editors (ICMJE),</span></strong></p> <p><strong><span class="tagline">Directory of Research Journals Indexing</span></strong></p> en-US International Journal Of Medicine Papers Immunoglobulins Concentrations in Patients with Chronic Rhinosinusitis <p class="Els-Abstract-text"><strong>Background and objective;</strong> It seems local secretory or systemic humoral immunodeficiency predisposes the individuals to rhinosinusitis. Although immunodeficiency was a subject of various researches but studies indicate it is a fertile subject of investigations. Therefore, in this trial we tried to reveal the role of Immunoglobulin G, its subclases, IgE and salivary IgA in chronic rhinosinusitis.</p><p class="Els-Abstract-text"><strong>Methodology:</strong> Study population included patients with chronic rhinosinusitis whom underwent immunoglobulins determination. Immunoglobulin G, IgG1, IgG2, IgG3, IgG4 were measured by MININEPHTM HUMAN IgG KIT (The binding site Ltd., Birmingham,UK) .Salivary IgA was evaluated by direct immunoenzymatic determination (DiaMetra,ITALY).Serum IgE was measured by enzyme linked immunoabsorbent assay (ELISA) (Monobind, USA). study was conducted in otorhinolaryngology, head and neck surgery department, Mazandaran University of medical sciences from January 2013 to September 2014.</p><p class="Els-Abstract-text"><strong>Results;</strong> this series included 22 (44%) male and 28(56%) female subjects suffered from chronic rhinosinusitis aged from 1 to 67 years (mean (SD): 28.06 ±15.49). In this study we observed 3 cases had IgG deficiency, IgG1, IgG 2, IgG 4 and salivary IgA deficiency were noted in 1, 2, 3 and 9 patients respectively.</p><p class="Els-Abstract-text"><strong>Conclusion:</strong> It appears that systemic and local defense mechanisms of the body response to pathogenic organisms and antigens by inducing the humoral immunity by elevating the level of antibodies in local and peripheral with IgG2 and salivary IgA being the majors’ up-regulated immunoglobulins.</p> Seyyed Abdollah Madani Seyyed Abbas Hashemi Mehran Fazli Ensiyeh Hajializadeh Kerdabadi ##submission.copyrightStatement## 2016-07-02 2016-07-02 1 1 Radial Artery Cannulation: Recommendations for Improved First Pass Success; Brief Report Radial artery cannulation is an important procedure in critical care medicine and cardiology. The risk of complications associated with arterial cannulation increases with the number of attempts. A review of the current literature was performed to identify recommendations to increase first pass success in radial artery cannulation. Recommendations include positioning the wrist at 45 degrees and the use of ultrasound. In ultrasound guided arterial cannulation, the choice of long axis versus short axis views should be based on proceduralist preference. Ruan Vlok Joshua Wall Thomas Melhuish Leigh White ##submission.copyrightStatement## 2016-11-04 2016-11-04 1 1 DNA methylation and cancer; A Review Article Epigenetics is the study of the changes in gene expression that are heritable and do not involve a change in the DNA sequence. DNA methylation is one of the key epigenetic mechanisms that is clearly understood. DNA methylation is the process that add methyl group to the 5th carbon atom of the cytosine base at CpG dinucleotides without changing the nucleotide sequence. Transcriptional silencing in X inactivation and genomic imprinting are two important epigenetic mechanisms where DNA methylation plays a major role. It is well known that DNA hypermethylation and hypomethylation are directly associated with tumor formation. Hypomethylation leads to the inappropriate and increased levels of gene expression in tumors. Trancriptional repression that is seen in cancers is also mostly due to hypermethylation. DNA methylation plays a major role in transcriptional silencing in X inactivation, genomic imprinting and tumor or cancer formation. Changes in the pattern of DNA methylation have been a consistent finding in cancer cells. DNA methylation plays an important role in the generation of mutations in human tumors. The high incidence of C-to-T transitions found in the p53 tumor-suppressor gene. DNA methylation plays a crucial role in the regulation of gene expression and chromatin organization within normal eukaryotic cells. In cancer patterns of DNA methylation are altered with global hypomethylation and hypermethylation of a subset of CpG-dense gene-associated regions (CpG islands). Maruf Raza A.K.M ##submission.copyrightStatement## 2016-11-09 2016-11-09 1 1 PATTERNS OF MORTALITY AMONG ADMITTED PATIENTS IN A TERTIARY CARE CENTRE IN NORTH INDIA. <p>Background</p><p>The mortality patterns among admitted patients in a hospital setting can reflect the overall burden of disease in a particular community although it does not provide an actual reflection of the situation.</p><p>Objective</p><p>To determine the etiology of mortality in admitted patients in a tertiary care hospital.</p><p>Material and methods</p><p>The study was carried prospectively in admitted patients over a period of 20 months. All patients who were admitted in the hospital during this time period who died due to one or the other cause were included in the study. The information obtained included age, sex, residence , diagnosis, reason for admission, duration of hospital stay and the possible cause of death.</p><p>Results</p><p>A total of 206 patients died over 20 months study period. Out of these, 112 (54.36% ) were males and 94 (45.63%) were females. Maximum deaths occurred in the age group 40-69 years (45.64%) followed by age group <span style="text-decoration: underline;"> &gt;</span> 70 years (40.77%).91 patients (44.17%) died of infections. Most common infections in the studied patients were pneumonias (48.34%)  followed by urinary tract infections (13.18%). Renal failure was seen in 68 (33%) patients. 33 (16.01%) died of myocardial infarction and 25 (12.13%) patients died of strokes. Maximum number of patients who died were in hospital for <span style="text-decoration: underline;">&lt;</span> 5 days that comprised of 123 (59.70%) patients.</p><p>Conclusion</p><p>The leading cause of death in this tertiary care hospital is infections followed by renal failure and ischemic heart disease.</p> Dr. Henna Naqash Dr.Mohammad Hayat Bhat Professor Parvaiz Ahmad Shah ##submission.copyrightStatement## 2016-11-12 2016-11-12 1 1 Oral Health Status and Treatment Needs Among SHCN Introduction: The provision of dental services to children with SHCN historically has been given limited attention by the dental profession. Under-diagnosis and differential oral health treatment contribute to the poor oral health of adults with disabilities. This study was done to assess the oral health status and behavior among those children.<br />Materials and Method: The study sample comprised of 317 subjects who were disabled and attending special schools. All the teeth were examined for dental caries. Mouth mirrors and CPI probes were used according to the WHO criteria. Clinical assessment of the oral health status was done by using the simplified oral hygiene index, DMFT. Chi square test and ANOVA were used to compare categorical variables.<br />Results: The study consists of 317 intellectually disabled (ID) children, divided into three groups, out of which 65 (20.50%), 184 (58.04%) and 68 (21.45%) were suffering from autism, cerebral palsy and mental retardation respectively. Irrespective of the type of disability, most of the subjects went to dentist only in need. The mean±SD decayed teeth in subjects with mental retardation, cerebral palsy and autism were 2.37±1.01, 1.91±1.50 and 1.75±1.11 respectively. 58.82% of the mentally retarded subjects reported with poor oral hygiene status.<br />Conclusion: In comparison with normal children, the disabled subjects were not given enough dental care with respect to their treatment needs. Taking into consideration the multi factorial influence on oral health status of the present disabled population, oral health promotion and intervention programs should be targeted and concentrated towards these risk groups. Vikram Pal Aggarwal Ashish Kakkar Sandeep Sidhu Shobit Singh ##submission.copyrightStatement## 2016-11-20 2016-11-20 1 1 Clinicopathological Study of Tuberculosis Patients in a Tertiary Care Medical College Hospital of Bangladesh Pulmonary tuberculosis is an air born infectious disease caused by Mycobacterium tuberculosis and is a major cause of morbidity and mortality particularly in developing countries. There are 33 million cases of tuberculosis worldwide, 3 million annual deaths and 8 million persons developed active tuberculosis every year. If tuberculosis is detected early and fully treated, people with the disease quickly become non-infectious and are eventually cured. However multi-drug resistance tuberculosis, HIV associated tuberculosis and weak health system are the major challenges. An observational study was conducted over a period of one year from September 2015 to August 2016 in the Outpatient Department of Jahurul Islam Medical College Hospital and Department of Pathology, Jahurul Islam Medical College, Kishoregonj, Bangladesh. Most of the patients were in the age group of 15-34 years (61.7%). 69.6% of the patients belonged to lower income group. 50.9% patients had pulmonary tuberculosis, 43.7% patients had extra pulmonary tuberculosis and 5.4% had both pulmonary and extra pulmonary tuberculosis. The most common symptoms observed in pulmonary tuberculosis patients were cough with expectoration (96.5%) followed by weight loss (80.7%), fever (73.7%) and loss of appetite (54.4%) whereas in extrapulmonary tuberculosis patient’s majority had weight loss (79.6%), fever (67,3%), loss of appetite (61.2%). AKM Maruf Raza Zaman Ahmed Shahriar Masood Mustafizur Rahman ##submission.copyrightStatement## 2016-11-20 2016-11-20 1 1