Immunoglobulins Concentrations in Patients with Chronic Rhinosinusitis

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Seyyed Abdollah Madani Seyyed Abbas Hashemi Mehran Fazli Ensiyeh Hajializadeh Kerdabadi

Abstract

Background and objective; It seems local secretory or systemic humoral immunodeficiency predisposes the individuals to rhinosinusitis. Although immunodeficiency was a subject of various researches but studies indicate it is a fertile subject of investigations. Therefore, in this trial we tried to reveal the role of Immunoglobulin G, its subclases, IgE and salivary IgA in chronic rhinosinusitis.

Methodology: Study population included patients with chronic rhinosinusitis whom underwent immunoglobulins determination. Immunoglobulin G, IgG1, IgG2, IgG3, IgG4 were measured by MININEPHTM HUMAN IgG KIT (The binding site Ltd., Birmingham,UK) .Salivary IgA was evaluated by direct immunoenzymatic determination (DiaMetra,ITALY).Serum IgE was measured by enzyme linked immunoabsorbent assay (ELISA) (Monobind, USA). study was conducted in otorhinolaryngology, head and neck surgery department, Mazandaran University of medical sciences from January 2013 to September 2014.

Results; this series included 22 (44%) male and 28(56%) female subjects suffered from chronic rhinosinusitis aged from 1 to 67 years (mean (SD): 28.06 ±15.49). In this study we observed 3 cases had IgG deficiency, IgG1, IgG 2, IgG 4 and salivary IgA deficiency were noted in 1, 2, 3 and 9 patients respectively.

Conclusion: It appears that systemic and local defense mechanisms of the body response to pathogenic organisms and antigens by inducing the humoral immunity by elevating the level of antibodies in local and peripheral with IgG2 and salivary IgA being the majors’ up-regulated immunoglobulins.

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