International Journal Of Biomedical Papers <p>ISSN: 2518-0754</p> <p>International Journal of biomedical papers takes pride in its leadership comprised of a wide range of disciplines in the field of biomedicine. IBJ is proud to offer a receptive medium for rapid, peer-reviewed publication for original articles (full length and short communication) as well as expert scientific reviews. It strives to maintain a dynamic growth of the quality of its publications and therefore, welcomes submissions in the following fields:</p> <p>1. Molecular Microbiology</p> <p>2. Molecular Genetics &amp; Genomics</p> <p>3. Molecular Immunology &amp; Vaccines</p> <p>4. Cancer Biology</p> <p>5. Pharmaceutical Biotechnology</p> <p>6. Medical Biotechnology</p> <p>7. Enzymology and Protein Chemistry</p> <p>8. Tissue Engineering and Cell Biology</p> <p>9. And Related Fields</p> <p>The purpose is to promote the interest of young medical and biomedical doctors toward research. Young fellows, specialist-in-training, PhD students, post-doc fellows and researchers may submit original manuscripts in English. Their works will be peer-reviewed from expert tutors that will guide the authors to improve their papers.</p> <p><em><strong>Submission</strong></em></p> <p><strong>Authors can send their papers through online submissions or as an email attachment to:</strong> <a href=""></a></p> <p>&nbsp;</p> <p>&nbsp;<a href="">Impact Factor=1.45</a></p> <p><strong>Indexed in</strong>:</p> <p><strong>Index Copernicus,</strong></p> <p><strong>CiteFactor,</strong></p> <p><strong>Genamics JournalSeek,</strong></p> <p><strong> Scientific World Index,</strong></p> <p><strong>J-Gate , </strong></p> <p><strong>Science Library Index,</strong></p> <p><strong> JournalGuide Directory of Journals,</strong></p> <p><strong> <span class="tagline">Geneva Foundation for Medical Education and Research,</span></strong></p> <p><strong><span class="tagline">ResearchBib, </span></strong></p> <p><strong><span class="tagline">Scientific Indexing Services (SIS database), </span></strong></p> <p><strong><span class="tagline">International Innovative Journal Impact Factor,</span></strong></p> <p><strong>Directory of Research Journals Indexing</strong></p> en-US International Journal Of Biomedical Papers Hystopathologic Effect of Allium Giganteum Extract on Diabetic Nephropathy in Syrian Male Mice <p class="Els-Abstract-text"><strong>Background and objective:</strong> Diabetic nephropathy is a clinical syndrome associated with albuminuria, progressive decrease of urination, and increased risk of cardiovascular diseases caused by pathologic changes in renal tissues. Diabetic nephropathy is the main cause of surgery of 25%-45% of patients undergoing kidney transplantation. Allium giganteum (native name, Lola) is a member of Liliaceae family. Some effective members of Liliaceae for diabetes and its complications are Allium sativum L. and Allium cepa L. The purpose of this study was to investigate the antinephropatic effect of the extract of Allium giganteum on Alloxan-induced diabetic small mice.</p><p class="Els-Abstract-text"><strong>Methods:</strong> 36 mice were randomly assigned into 6 groups. To induce diabetes, Alloxan was administered through intra peritoneal injection at dose of 150mg/kg. Then, the extract of Allium giganteum was administrated orally through orogastric tube at doses of 2gr/kg and 3gr/kg. After 30 days the tissues of kidney and liver of mice was hystopathologically investigated.</p><p class="Els-Abstract-text"><strong>Results:</strong> Administration of the extract of Allium giganteum at dose of 3gr/kg was more effective for kidney and liver tissues compared to 2gr/kg. Also, protective changes of kidney and liver tissues of mice received the extract of Allium giganteum were obvious compared with control diabetic group. The tissues of nondiabetic members that received the extract did not change and were similar to normal tissues.</p><p class="Els-Abstract-text"><strong>Conclusions:</strong> The extract of Allium giganteum had a significant protective effect against stress caused by diabetes in kidney and liver tissues of diabetic mice.</p> Mehran Fazli Nematollah Ahangar Fatemeh Fathiazad Iman Sadeghian Mohammad Esmail Kordjazi Ensiyeh Hajializadeh Kerdabadi ##submission.copyrightStatement## 2016-07-02 2016-07-02 1 1 Phytochemical Analyses and Anti-Microbial Effects of Alstonia boonei (De Wild), Bridelia ferrugenea (Benth), Eucalyptus tereticornis (Dehnh), Terminalia schimperiana (Hochst) and Polyalthia longifolia (Sonn) Thwaites. <p><strong>Background and Objectives:</strong> This study examined the bioactive ingredients and anti-bacterial activities of five medicinal plants – <em>Alstonia boonei</em><em>,</em> <em>Bridelia ferrugenea, </em><em>Eucalyptus tereticornis, Terminalia schimperiana </em>and<em> </em><em>Polyalthia longifolia – </em>used traditionally in the study area. This study aimed at validating, scientifically, the ethnobotanical utilization of these species.</p><p><strong>Methods:</strong> The leaves and stem barks of these plants were collected, dried made to powders. The powdered leaves and stems were extracted using aqueous and ethanol solvent. The extracts were used for the preliminary phytochemical screening and antimicrobial studies using standard methods.</p><p><strong>Results:</strong> The plants were found to contain tannins, saponins, flavonoids, alkaloids, cardiac glycosides and terpenoids. Extracts from these plants, at high concentration (100mg/ml), inhibited the growth of the bacteria studied. <em>Salmonella typhi</em> was the most resistance organism (at 100mg/ml) while <em>Staphlococcus </em>spp strains were the most sensitive organisms to both aqueous and ethanol extracts of all the plants at varying concentrations. The ethanol solvent extracted the phyto- chemicals in the plants better than water extract.</p><p><strong>Conclusion:</strong> The results obtained in this study demonstrated the potencies of these species on the bacterial isolates of <em>Staphlococcus aureus</em>, <em>Escherichia coli, Enterococcus faecalis</em> and <em>Salmonella typhi</em> (at 50mg/ml and 100 mg/ml). Thus, confirming their suitability in the traditional treatments of diseases, such as dysentery, diarrhea, malaria and typhoid fever.</p> Olanipekun Mary K Adedeji Damilola E Kayode Joshua David O.Moses Adewuyi Damilare ##submission.copyrightStatement## 2016-09-03 2016-09-03 1 1 Barks Extravitism and Healthiness of Aboriginal Yoruba Populace in Kwara State, Nigeria Background and Objectives: The studies conducted on plant barks used in native pharmaceutical extraction in Yoruba-speaking areas of Nigeria have failed to consider the Yoruba ethnic groups of Kwara and Kogi States of the country Nigeria. Thus this study is an attempt to fill the missing gap and aimed at the identification of plant species whose barks are extracted in Yoruba speaking area of Kwara State for medicinal purposes and define their chemical constituents.<br />Methods: Two rural communities were selected from each of the 12 Yoruba speaking Local Government Areas (LGAs) of Kwara State and used for this study. 10 respondents were randomly selected in each community and interviewed with the aid of a semi-structured questionnaire guide. Also in each LGA, a major market was selected where 5 botanical vendors were interviewed on the plant barks sold in the market. All the interviewed were focused, conversational and two-way in communication. Group interviews were conducted in each community to established group consensus on the individual responses provided. Key informants, consisting of health, forestry and community development officers were identified in each LGA and interviewed.<br />Results: The Yoruba tribe in Kwara State have cultural affiliation with their tribe in the south western parts of the country. They passed ethnobotanical knowledge from one generation to another. Dependence on the use of medicinal plants for health management was prominent in this culture. A total of 40 plants, belonging to 23 families, were observed to have their barks valued as medicine and/or for health maintenance in the study area. Secondary sources revealed the various chemical constituents of the identified species. The method of utilization of the species varied from soaking in cold water or soft drink for prescribed periods, to boiling in water, grinding and taken with water or Pap or honey, chewing and ingesting of the resulting saliva.<br />Conclusion: Plant barks were observed to be useful to the healthiness of the tribal Yoruba group in Kwara State, Nigeria. Incentives and disincentives that could affect continuous utilization were identified. Kayode J. Amoo J.O Ayeni M.J ##submission.copyrightStatement## 2016-12-10 2016-12-10 1 1