Hystopathologic Effect of Allium Giganteum Extract on Diabetic Nephropathy in Syrian Male Mice

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Mehran Fazli Nematollah Ahangar Fatemeh Fathiazad Iman Sadeghian Mohammad Esmail Kordjazi Ensiyeh Hajializadeh Kerdabadi

Abstract

Background and objective: Diabetic nephropathy is a clinical syndrome associated with albuminuria, progressive decrease of urination, and increased risk of cardiovascular diseases caused by pathologic changes in renal tissues. Diabetic nephropathy is the main cause of surgery of 25%-45% of patients undergoing kidney transplantation. Allium giganteum (native name, Lola) is a member of Liliaceae family. Some effective members of Liliaceae for diabetes and its complications are Allium sativum L. and Allium cepa L. The purpose of this study was to investigate the antinephropatic effect of the extract of Allium giganteum on Alloxan-induced diabetic small mice.

Methods: 36 mice were randomly assigned into 6 groups. To induce diabetes, Alloxan was administered through intra peritoneal injection at dose of 150mg/kg. Then, the extract of Allium giganteum was administrated orally through orogastric tube at doses of 2gr/kg and 3gr/kg. After 30 days the tissues of kidney and liver of mice was hystopathologically investigated.

Results: Administration of the extract of Allium giganteum at dose of 3gr/kg was more effective for kidney and liver tissues compared to 2gr/kg. Also, protective changes of kidney and liver tissues of mice received the extract of Allium giganteum were obvious compared with control diabetic group. The tissues of nondiabetic members that received the extract did not change and were similar to normal tissues.

Conclusions: The extract of Allium giganteum had a significant protective effect against stress caused by diabetes in kidney and liver tissues of diabetic mice.

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