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A field trial was conducted at the Spices Research Center, BARI, Shibganj, Bogra during 2009-10 to study the effect of different management practices to control of rhizome rot and best economic return on the growth and yield of ginger. Ginger cv. BARI Ada-1 was planted 1st week of April. Six treatments were used viz., C1 (solarization of soil), C2 (burning of soil by rice straw), C3 (burning of soil by saw dust), C4 (neem cake), C5 (mustard oil cake) and C6 (control). The treatment was arranged in Randomize Complete Block Design using with three replications. The results reveled that C4 (neem cake) showed early emergence, highest plant height, number of leaves plant-1, number of tillers plant-1 with maximum weight of primary rhizome and secondary rhizome, highest dry matter % and weight of old mother rhizome tha-1. The highest yield of rhizome (18.02 tha-1) and best benefit cost ratio (2.25) was also recorded in the C4 (neem cake). From the results, it can be concluded that C4 (neem cake 2.0 tha-1) treatment produced higher yield and best benefit cost ratio for ginger cultivation in northern region of Bangladesh.